ABSTRACT: Binge alcohol consumption in the rat induces substantial neurodegeneration in the hippocampus andentorhinal cortex. Oxidative stress and cytotoxic edema have both been shown to be involved in such neurotoxicity, whereas N-methyl-D-aspartate (NMDA) receptor activity has been implicated in alcohol withdrawal and excitoxic injury. Because the nonpsychoactive ... Continue Reading