ABSTRACT: Cannabinoids are a group of compounds present in Cannabis plant (Cannabis sativa L.). They mediate their physiological and behavioral effects by activating specific cannabinoid receptors. With the recent discovery of the cannabinoid receptors (CB1 and CB2) and the endocannabinoid system, research in this field has expanded exponentially. Cannabinoids have been ... Continue Reading
apoptosis
STUDY: Molecular Mechanisms Involved in the Antitumor Activity of Cannabinoids on Gliomas: Role for Oxidative Stress
ABSTRACT: Cannabinoids, the active components of Cannabis sativa, have been shown to exert antiproliferative and proapoptotic effects on a wide spectrum of tumor cells and tissues. Of interest, cannabinoids have displayed great potency in reducing the growth of glioma tumors, one of the most aggressive CNS tumors, either in vitro or in animal experimental models curbing the ... Continue Reading
STUDY: The endocannabinoid system and cancer: therapeutic implication
ABSTRACT: The endocannabinoid system is implicated in a variety of physiological and pathological conditions (inflammation, immunomodulation, analgesia, cancer and others). The main active ingredient of cannabis, Δ9-tetrahydrocannabinol (Δ9-THC), produces its effects through activation of CB1 and CB2 receptors. CB1 receptors are expressed at high levels in the central nervous ... Continue Reading
Cannabis Cures Brain Cancer: Clinical Trials Set to Kick Off This Year
In this post from Counter Current News, M. David and Jackson Marciana report that clinical trials to demonstrate the effectiveness of cannabis in curing brain cancer are set to kick off this year, and once the evidence is in, the government is going to have a lot of explaining to do… With all of the growing scientific evidence in favor of marijuana use for both curative and ... Continue Reading
STUDY: Melanoma – Cyclohexa-2,5-diene-1,4-dione-based antiproliferative agents: design, synthesis, and cytotoxic evaluation
ABSTRACT: Background Tumors are diseases characterized by uncontrolled cell growth and, in spite of the progress of medicine over the years, continue to represent a major threat to the health, requiring new therapies. Several synthetic compounds, such as those derived from natural sources, have been identified as anticancer drugs; among these compounds quinone represent the ... Continue Reading