For cardiovascular health, consider cannabis high in CBD. This post from The Fresh Toast highlights how CBD benefits your heart by reducing the blood pressure. For decades, scientists have debated the effect marijuana has on the cardiovascular system. There was no clinical consensus and most of the studies focused primarily on THC, the psychoactive component in cannabis. But ... Continue Reading
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STUDY: Cardiovascular Pharmacology of Cannabinoids
ABSTRACT: Cannabinoids and their synthetic and endogenous analogs affect a broad range of physiological functions, including cardiovascular variables, the most important component of their effect being profound hypotension. The mechanisms of the cardiovascular effects of cannabinoids in vivo are complex and may involve modulation of autonomic outflow in both the central and ... Continue Reading
STUDY: GPR55 and the vascular receptors for cannabinoids
ABSTRACT: CB1 and CB2 receptors mediate most responses to cannabinoids but not some of the cardiovascular actions of endocannabinoids such as anandamide and virodhamine, or those of some synthetic agents, like abnormal cannabidiol (abn-cbd). These agents induce vasorelaxation which is antagonised by rimonabant but only at high concentrations relative to those required to ... Continue Reading
STUDY: Hypotension – The Novel Endocannabinoid Receptor GPR18 Is Expressed in the Rostral Ventrolateral Medulla and Exerts Tonic Restraining Influence on Blood Pressure
ABSTRACT: Systemic administration of the G-protein–coupled receptor 18 (GPR18) agonist abnormal cannabidiol (Abn CBD) lowers blood pressure (BP). Whether GPR18 is expressed in the central nervous system (CNS) and plays a role in BP control is not known despite the abundance of the GPR18 ligand N-arachidonoyl glycine (NAGly) in the CNS. Therefore, we first determined whether ... Continue Reading