ABSTRACT: Increased cannabis potency has renewed concerns that secondhand exposure to cannabis smoke can produce positive drug tests. A systematic study was conducted of smoke exposure on drug-free participants. Six experienced cannabis users smoked cannabis cigarettes (5.3% THC in Session 1 and 11.3% THC in Sessions 2 and 3) in a sealed chamber. Six non-smokers were seated ... Continue Reading
cannabid
STUDY: Factors that lead to the use of crack cocaine in combination with marijuana in Brazil: a qualitative study
ABSTRACT: Background In Brazil, crack cocaine use remains a healthcare challenge due to the rapid onset of its pleasurable effects, its ability to induce craving and addiction, and the fact that it is easily accessible. Delayed action on the part of the Brazilian Government in addressing the drug problem has led users to develop their own strategies forsurviving the effects ... Continue Reading
STUDY: Why should Cannabis be Considered Doping in Sports?
ABSTRACT: Recent debate and cases involving elite athletes raised the question whether or not Cannabis sativa (cannabis) should be considered doping in sports. Results from a 2010 report in the United States (Substance Abuse and Mental Health Services Administration,2011) showed that cannabis is the most used illicit drug, with 17.4 million users smoking cannabis and 6.9 ... Continue Reading
STUDY: Fine-tuning of defensive behaviors in the dorsal periaqueductal gray by atypical neurotransmitters
ABSTRACT: This paper presents an up-to-date review of the evidence indicating that atypical neurotransmitters such as nitric oxide (NO) and endocannabinoids (eCBs) play an important role in the regulation of aversive responses in the periaqueductal gray (PAG). Among the results supporting this role, several studies have shown that inhibitors of neuronal NO synthase or ... Continue Reading
STUDY: Activation of Cannabioid Receptor 2 Attenuates Leukocyte-Endothelial Interactions and Blood-Brain Barrier Dysfunction under Inflammatory Conditions
ABSTRACT: Previous studies have shown that modulation of the receptor-mediated cannabinoid system during neuroinflammation can produce potent neuroprotective and anti-inflammatory effects. However in this context, little is known about how selective activation of the cannabinoid type-2 receptor (CB2R) affects the activated state of the brain endothelium and blood brain ... Continue Reading