ABSTRACT: Analyte stability is an important factor in urine test interpretation, yet cannabinoid stability data are limited. A comprehensive study of Δ9-tetrahydrocannabinol (THC), 11-hydroxy-THC (11-OH-THC), 11-nor-9-carboxy-THC (THCCOOH), cannabidiol, cannabinol, THC-glucuronide, and THCCOOH-glucuronide stabilities in authentic urine was completed. Urine samples after ad ... Continue Reading
cannabis dependence
STUDY: Oral fluid cannabinoid concentrations following controlled smoked cannabis in chronic frequent and occasional smokers
ABSTRACT: Background Oral fluid (OF) is an alternative biological matrix for monitoring cannabis intake in drug testing, and drugged driving (DUID) programs, but OF cannabinoid test interpretation is challenging. Controlled cannabinoid administration studies provide a scientific database for interpreting cannabinoid OF tests. Methods We compared differences in OF ... Continue Reading
STUDY: Disposition of Cannabinoids in Oral Fluid after Controlled Around-the-Clock Oral THC Administration
ABSTRACT: Background Oral fluid, a promising alternative matrix for drug monitoring in clinical and forensic investigations, offers noninvasive sample collection under direct observation. Cannabinoid distribution into oral fluid is complex and incompletely characterized due to the lack of controlled drug administration studies. Methods To characterize cannabinoid ... Continue Reading
STUDY: Cannabis Dependence – Risks Associated With the Non-Medicinal Use of Cannabis
ABSTRACT: Background Cannabis is the most commonly consumed illicit drug around the world; in Germany, about 4.5% of all adults use it each year. Intense cannabis use is associated with health risks. Evidence-based treatments are available for health problems caused by cannabis use. Methods Selective literature review based on a search of the PubMed database, with ... Continue Reading
STUDY: Cannabis Dependence – Cannabidiol Attenuates the Appetitive Effects of Δ9-Tetrahydrocannabinol in Humans Smoking Their Chosen Cannabis
ABSTRACT: Worldwide cannabis dependence is increasing, as is the concentration of Δ9-tetrahydrocannabinol (THC) in street cannabis. At the same time, the concentration of the second most abundant cannabinoid in street cannabis, cannabidiol (CBD), is decreasing. These two cannabinoids have opposing effects both pharmacologically and behaviorally when administered in the ... Continue Reading