ABSTRACT: 1. In anaesthetized rats, intravenous administration of cannabis extract (10 mg/kg), Δ1-tetrahydrocannabinol (THC) (0·5 mg/kg) and Δ6-THC (0·5 mg/kg) caused a reduction in systemic blood pressure, pulse rate and respiratory rate. 2. Neither cannabinol (1 mg/kg, i.v.) nor cannabidiol (1 mg/kg, i.v.) had any observed effects on the cardiovascular and respiratory ... Continue Reading