ABSTRACT: Previous studies have shown that modulation of the receptor-mediated cannabinoid system during neuroinflammation can produce potent neuroprotective and anti-inflammatory effects. However in this context, little is known about how selective activation of the cannabinoid type-2 receptor (CB2R) affects the activated state of the brain endothelium and blood brain ... Continue Reading
CB2
STUDY: Cannabinoid 2 (CB2) receptor involvement in the down-regulation but not up-regulation of serum IgE levels in immunized mice
ABSTRACT: Marijuana cannabinoids such as Δ9-tetrahydrocannabinol (THC) have been shown in experimental systems to bias T helper immunity towards Th2 and away from Th1. This effect if broadly applicable to humans could have important implications in Th2-mediated diseases such as allergy. In the current study, we examined the effect of cannabinoids on serum immunoglobulin IgE ... Continue Reading
STUDY: Targeting the Endocannabinoid System in Alzheimer’s Disease
ABSTRACT: The endocannabinoid system is rapidly emerging as a potential drug target for a variety of immune-mediated central nervous system diseases. There is a growing body of evidence suggesting that endocannabinoid interventions may have particular relevance to Alzheimer's disease. Here we present a review of endocannabinoid physiology, the evidence that underscores its ... Continue Reading
STUDY: New blood brothers: the GPR55 and CB2 partnership
ABSTRACT: Endocannabinoids are increasingly being recognized as key lipid-derived regulators of immune function 1. Although the peripheral cannabinoid type 2 receptor (CB2) is thought to orchestrate many of these actions, additional non-CB1/CB2-mediated effects of cannabinoids have been identified in immune cells 1, 2, where several orphan G protein-coupled receptors ... Continue Reading
STUDY: Emerging Role of the CB2 Cannabinoid Receptor in Immune Regulation and Therapeutic Prospects
ABSTRACT: There is now a large body of data that indicates that the CB2 cannabinoid receptor type 2 (CB2) is linked to a variety of immune functional events. This functional relevance appears to be most salient in the course of inflammation, a process during which there is an increased number of receptors that are available for activation. Studies aimed at elucidating signal ... Continue Reading