ABSTRACT: Background and purpose: We aimed to demonstrate the involvement of 5-HT1A receptors in the therapeutic effect of cannabidiol, a non-psychoactive constituent of Cannabis sativa, in a model of hepatic encephalopathy induced by bile-duct ligation (BDL) in mice. Experimental approach: Cannabidiol (5 mg·kg−1; i.p.) was administered over 4 weeks to BDL mice. ... Continue Reading