ABSTRACT: The CB1 and CB2 cannabinoid receptors are members of the G protein-coupled receptor (GPCR) family that are pharmacologically well defined. However, the discovery of additional sites of action for endocannabinoids as well as synthetic cannabinoid compounds suggests the existence of additional cannabinoid receptors. Here we review this evidence, as well as the ... Continue Reading
G-protein-coupled receptor
STUDY: Pharmacological Characterization of GPR55, A Putative Cannabinoid Receptor
ABSTRACT: GPR55 has recently attracted much attention as another member of the cannabinoid family, potentially explaining physiological effects that are non-CB1/CB2 mediated. However, the data gathered so far are conflicting with respect to its pharmacology. We review the primary literature to date on GPR55, describing its discovery, structure, pharmacology and potential ... Continue Reading
STUDY: The orphan receptor GPR55 is a novel cannabinoid receptor
ABSTRACT: Background: The endocannabinoid system functions through two well characterized receptor systems, the CB1 and CB2receptors. Work by a number of groups in recent years has provided evidence that the system is more complicated and additional receptor types should exist to explain ligand activity in a number of physiological processes. Experimental ... Continue Reading