ABSTRACT: Cannabinoids enhance the function of glycine receptors (GlyRs). However, little is known about the mechanisms and behavioral implication of cannabinoid-GlyR interaction. Using mutagenesis and NMR analysis, we have identified a serine at 296 in the GlyR protein critical for the potentiation of IGlyby Δ9-tetrahydrocannabinol (THC), a major psychoactive component of ... Continue Reading