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immunomodulation

STUDY: The role of transient receptor potential vanilloid type-2 ion channels in innate and adaptive immune responses

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ABSTRACT: The transient receptor potential vanilloid type-2 (TRPV2), belonging to the transient receptor potential channel family, is a specialized ion channel expressed in human and other mammalian immune cells. This channel has been found to be expressed in CD34+ hematopoietic stem cells, where its cytosolic Ca2+ activity is crucial for stem/progenitor cell cycle ... Continue Reading

STUDY: HIV-Magnitude of stimulation dictates the cannabinoid-mediated differential T cell response to HIVgp120

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ABSTRACT: Approximately 25% of immunocompromised HIV patients smoke marijuana for its putative therapeutic benefit. The goal of these studies was to test the hypothesis that marijuana-derived cannabinoids have immunomodulatory effects on HIV antigen-specific T cell effector function. A surrogate mouse model to induce polyclonal T cell responses against HIVgp120 was ... Continue Reading

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