ABSTRACT: Growing evidence suggests that a major physiological function of the cannabinoid signaling system is to modulate neuroinflammation. This review discusses the anti-inflammatory properties of cannabinoid compounds at molecular, cellular and whole animal levels, first by examining the evidence for anti-inflammatory effects of cannabinoids obtained using in vivo animal ... Continue Reading
Inflammation
STUDY: Inflammation – CB2 receptor-mediated migration of immune cells: it can go either way
ABSTRACT: Though many studies have examined the role of CB2 receptors in immune cell migration, it has been difficult to form definitive conclusions about the physiopathological role of these receptors in regulating immune responses and how this might be pharmacologically targeted for therapy. Do cannabinoids promote inflammation through the recruitment of immune cells, or ... Continue Reading
STUDY: Sepsis – Interplay between inflammation, immune system and neuronal pathways: Effect on gastrointestinal motility
ABSTRACT: Sepsis is a systemic inflammatory response representing the leading cause of death in critically ill patients, mostly due to multiple organ failure. The gastrointestinal tract plays a pivotal role in the pathogenesis of sepsis-induced multiple organ failure through intestinal barrier dysfunction, bacterial translocation and ileus. In this review we address the role ... Continue Reading
STUDY: Cannabinoids: clearing the smoke on pain, inflammation and neurodegeneration
ABSTRACT: This themed section of BJP arises from the 6th European Workshop on Cannabinoid Research held in Dublin, Ireland from 18–20 April 2013. The section brings together 3 reviews and 10 research articles, presenting a range of work across the cannabinoid field. The review article by Fagan et al. (2014) addresses the impact of endogenous, plant-derived and synthetic ... Continue Reading
STUDY: Autoimmune Disease – Do Cannabinoids have a therapeutic role in transplantation?
ABSTRACT: Cannabinoids have emerged as powerful drug candidates for the treatment of inflammatory and autoimmune diseases due to their immunosuppressive properties. While significant clinical and experimental data on the use of cannabinoids as anti-inflammatory agents exist in many autoimmune disease settings, virtually no studies have been performed on their potential role ... Continue Reading