ABSTRACT: Background and purpose: We have recently shown that the phytocannabinoid Δ9-tetrahydrocannabivarin (Δ9-THCV) and the CB1 receptor antagonist AM251 increase inhibitory neurotransmission in mouse cerebellum and also exhibit anticonvulsant activity in a rat piriform cortical (PC) model of epilepsy. Possible mechanisms underlying cannabinoid actions in the CNS include ... Continue Reading