Benefits of CBD in treating psychiatric/cognitive symptoms, associated with neurodegeneration, are being explored by scientists. This post from The Joint Blog discusses the findings of a new study. Cannabidiol (CBD) may be beneficial in the treatment of psychiatric/cognitive symptoms associated with neurodegeneration, according to a new study. The study, published by the ... Continue Reading
neurodegeneration
STUDY: Evaluation of Phytocannabinoids from High Potency Cannabis sativa using In Vitro Bioassays to Determine Structure-Activity Relationships for Cannabinoid Receptor 1 and Cannabinoid Receptor 2
ABSTRACT: Cannabis has been around for thousands of years and has been used recreationally, medicinally, and for fiber. Over 500 compounds have been isolated from Cannabis sativawith approximately 105 being cannabinoids. Of those 105 compounds, Δ9-tetrahydrocannabinol has been determined as the primary constituent, which is also responsible for the psychoactivity associated ... Continue Reading
STUDY: Prion Pathogenesis Is Faithfully Reproduced in Cerebellar Organotypic Slice Cultures
ABSTRACT: Prions cause neurodegeneration in vivo, yet prion-infected cultured cells do not show cytotoxicity. This has hampered mechanistic studies of prion-induced neurodegeneration. Here we report that prion-infected cultured organotypic cerebellar slices (COCS) experienced progressive spongiform neurodegeneration closely reproducing prion disease, with three different ... Continue Reading
STUDY: Cannabinoid receptor signalling in neurodegenerative diseases: a potential role for membrane fluidity disturbance
ABSTRACT: Type-1 cannabinoid receptor (CB1) is the most abundant G-protein-coupled receptor (GPCR) in the brain. CB1 and its endogenous agonists, the so-called ‘endocannabinoids (eCBs)’, belong to an ancient neurosignalling system that plays important functions in neurodegenerative and neuroinflammatory disorders like Alzheimer's disease, Parkinson's disease, amyotrophic ... Continue Reading
STUDY: Cannabinoids: clearing the smoke on pain, inflammation and neurodegeneration
ABSTRACT: This themed section of BJP arises from the 6th European Workshop on Cannabinoid Research held in Dublin, Ireland from 18–20 April 2013. The section brings together 3 reviews and 10 research articles, presenting a range of work across the cannabinoid field. The review article by Fagan et al. (2014) addresses the impact of endogenous, plant-derived and synthetic ... Continue Reading