ABSTRACT: Cannabidiol (CBD), a Cannabis sativa constituent, is a pharmacologically broad-spectrum drug that in recent years has drawn increasing interest as a treatment for a range of neuropsychiatric disorders. The purpose of the current review is to determine CBD’s potential as a treatment for anxiety-related disorders, by assessing evidence from preclinical, human ... Continue Reading
Post traumatic stress disorder
STUDY: Targeting the endocannabinoid system to treat haunting traumatic memories
ABSTRACT: One of the core symptoms in post-traumatic stress disorder (PTSD) is the traumatic memory that constantly haunts the patient. PTSD is a paradoxical disorder of memory—on the one hand, intrusive recollections for certain aspects of the event and, on the other hand, amnesia for other important aspects (Ehlers et al., 2004). Intrusive memories, often triggered ... Continue Reading
STUDY: The endocannabinoid system as a possible target to treat both the cognitive and emotional features of post-traumatic stress disorder (PTSD)
ABSTRACT: Post-traumatic stress disorder (PTSD) is a psychiatric disorder of significant prevalence and morbidity, whose pathogenesis relies on paradoxical changes of emotional memory processing. An ideal treatment would be a drug able to block the pathological over-consolidation and continuous retrieval of the traumatic event, while enhancing its extinction and reducing the ... Continue Reading
STUDY: PTSD – Cannabinoid modulation of prefrontal-limbic activation during fear extinction learning and recall in humans
ABSTRACT: Pre-extinction administration of ∆9-tetrahydrocannibinol (THC) facilitates recall of extinction in healthy humans, and evidence from animal studies suggest that this likely involves via enhancement of the cannabinoid system within the ventromedial prefrontal cortex (vmPFC) and hippocampus (HIPP), brain structures critical to fear extinction. However, the effect of ... Continue Reading