There are many remarkable things about cannabis. It has an enticing smell, lovely appearance, multiple uses, and outstanding health benefits. Interestingly, these characteristics are nearly all impacted by the compound profile of this beautiful plant. Perhaps the best-known compound manufactured in cannabis is the cannabinoid Δ9- tetrahydrocannabinol, or just ... Continue Reading
tetrahydrocannabinol
STUDY: The role of halogen substitution in classical cannabinoids: A CB1 pharmacophore model
ABSTRACT: The presence of halogens within the classical cannabinoid structure leads to large variations in the compounds' potencies and affinities for the CB1 receptors. To explore the structure activity relationships within this class of analogs we have used a series of halogen-substituted (−)-Δ8-tetrahydrocannabinol analogs and compared their affinities for the CB1 ... Continue Reading
STUDY: Evaluation of Phytocannabinoids from High Potency Cannabis sativa using In Vitro Bioassays to Determine Structure-Activity Relationships for Cannabinoid Receptor 1 and Cannabinoid Receptor 2
ABSTRACT: Cannabis has been around for thousands of years and has been used recreationally, medicinally, and for fiber. Over 500 compounds have been isolated from Cannabis sativawith approximately 105 being cannabinoids. Of those 105 compounds, Δ9-tetrahydrocannabinol has been determined as the primary constituent, which is also responsible for the psychoactivity associated ... Continue Reading
STUDY: So what do we call GPR18 now?
ABSTRACT: The further characterization of the orphan GPCR GPR18 conducted by McHugh et al. in this issue of the British Journal of Pharmacology has generated a pharmacological profile that raises some interesting questions about the nomenclature of this receptor and may also prompt some questions about the pharmacological definition of the classical cannabinoid receptors, CB1 ... Continue Reading
STUDY: Withdrawal from THC during Adolescence: Sex Differences in Locomotor Activity and Anxiety
ABSTRACT: Research suggests that the use and abuse of marijuana can be especially harmful if it occurs during adolescence, a period of vast developmental changes throughout the brain. Due to the localization of cannabinoid receptors within the limbic system and the established effects of cannabinoids on emotional states and anxiety levels of rats and humans, we studied the ... Continue Reading