Researchers have found a surprising link between the cannabinoids, the brain’s endocannabinoid system, and the runner’s high. Learn more in this post from Leafly. If you are (or you’ve ever been) an avid runner or obsessive gym rat, you’re likely familiar with that coveted post-workout sense of euphoria popularized as the “runner’s high.” But what exactly is it? The runner’s ... Continue Reading
anandamide
The Cannabinoids in Weed That Get You High
If marijuana is the foreman, the cannabinoids are the construction crew. This post from Inverse Science explains how the chemicals in weed plot together to get you high! You might think of the process as simple: Light up a joint, inhale, let the dank gas permeate your lungs. But smoking pot is a lot more complex than you might think. Let’s start with the cannabinoids. They’re ... Continue Reading
STUDY: Endocannabinoids and the Heart
ABSTRACT: Endocannabinoids, such as anandamide and 2-arachidonoylglycerol, are synthesized from membrane phospholipids in the heart and other cardiovascular tissues. They activate cannabinoid CB1 and CB2 receptors, TRPV1, peroxisome proliferator-activated receptors and perhaps a novel vascular G-protein-coupled receptor. Inactivation is by cellular uptake and fatty acid ... Continue Reading
STUDY: Endocannabinoids as Guardians of Metastasis
ABSTRACT: Endocannabinoids including anandamide and 2-arachidonoylglycerol are involved in cancer pathophysiology in several ways, including tumor growth and progression, peritumoral inflammation, nausea and cancer pain. Recently we showed that the endocannabinoid profiles are deranged during cancer to an extent that this manifests in alterations of plasma endocannabinoids ... Continue Reading
STUDY: Anandamide Attenuates Th-17 Cell-Mediated Delayed-Type Hypersensitivity Response by Triggering IL-10 Production and Consequent microRNA Induction
ABSTRACT: Endogenous cannabinoids [endocannabinoids] are lipid signaling molecules that have been shown to modulate immune functions. However, their role in the regulation of Th17 cells has not been studied previously. In the current study, we used methylated Bovine Serum Albumin [mBSA]-induced delayed type hypersensitivity [DTH] response in C57BL/6 mice, mediated by Th17 ... Continue Reading