ABSTRACT: Rich evidence has shown that cannabis products exert a broad gamut of effects on emotional regulation. The main psychoactive ingredient of hemp, Δ9-tetrahydrocannabinol (THC), and its synthetic cannabinoid analogs have been reported to either attenuate or exacerbate anxiety and fear-related behaviors in humans and experimental animals. The heterogeneity of ... Continue Reading
Anxiety
STUDY: Anxiety – Subjective and Physiological Effects After Controlled Sativex and Oral THC Administration
ABSTRACT: Sativex is a cannabis-plant extract delivering nearly 1:1 Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD) by oromucosal spray. It has been suggested that CBD attenuates THC-induced tachycardia, anxiety, and euphoria. In this study, pharmacodynamic effects were compared over 10.5 h in nine cannabis smokers randomly assigned to receive placebo, 5 and 15 mg ... Continue Reading
STUDY: Epilepsy – Taming THC: potential cannabis synergy and phytocannabinoid-terpenoid entourage effects
ABSTRACT: Tetrahydrocannabinol (THC) has been the primary focus of cannabis research since 1964, when Raphael Mechoulam isolated and synthesized it. More recently, the synergistic contributions of cannabidiol to cannabis pharmacology and analgesia have been scientifically demonstrated. Other phytocannabinoids, including tetrahydrocannabivarin, cannabigerol and cannabichromene, ... Continue Reading
STUDY: Modulation of cognitive and emotional processing by cannabidiol: the role of the anterior cingulate cortex
ABSTRACT: Cannabis sativa is a plant containing over 70 active compounds called cannabinoids (Schoedel and Harrison, 2012). The psychoactive effects of cannabinoids are abused worldwide by about 20% of young people, who report regular or heavy use of the cannabis plant (Moore et al., 2007). Delta-9-tetrahydrocannabinol (THC), the most prevalent cannabinoid in the plant, has ... Continue Reading
STUDY: Facial Affect – Acute effects of delta-9-tetrahydrocannabinol, cannabidiol and their combination on facial emotion recognition: A randomised, double-blind, placebo-controlled study in cannabis users
ABSTRACT: Acute administration of the primary psychoactive constituent of cannabis, Δ-9-tetrahydrocannabinol (THC), impairs human facial affect recognition, implicating the endocannabinoid system in emotional processing. Another main constituent of cannabis, cannabidiol (CBD), has seemingly opposite functional effects on the brain. This study aimed to determine the effects ... Continue Reading