ABSTRACT: Objectives. Marijuana is the most commonly used illicit drug during pregnancy. Due to high lipophilicity, cannabinoids can easily penetrate physiological barriers like the human placenta and jeopardize the developing fetus. We evaluated the impact of cannabidiol (CBD), a major non-psychoactive cannabinoid, on P-glycoprotein (P-gp) and Breast Cancer Resistance Protein ... Continue Reading
Breast Cancer
STUDY: Compartmentalization of endocannabinoids into lipid rafts in a microglial cell line devoid of caveorrlin-1
ABSTRACT BACKGROUND AND PURPOSE N-acyl ethanolamines (NAEs) and 2-arachidonoyl glycerol (2-AG) are endogenous cannabinoids and along with related lipids are synthesized on demand from membrane phospholipids. Here, we have studied the compartmentalization of NAEs and 2-AG into lipid raft fractions isolated from the caveolin-1-lacking microglial cell line BV-2, following ... Continue Reading
Research Shows Cannabidiol Deters Aggressive Breast Cancer
A new study published in the journal Molecular Oncology, and published online by the National Institute of Health, has found that the cannabis compound cannabidiol inhibits the growth and metastasis of highly aggressive breast cancer NEW STUDY FINDS CANNABIDIOL INHIBITS GROWTH OF HIGHLY AGGRESSIVE BREAST CANCER “The anti-tumor role and mechanisms of Cannabidiol (CBD), a ... Continue Reading
STUDY: Pathways mediating the effects of cannabidiol on the reduction of breast cancer cell proliferation, invasion, and metastasis
ABSTRACT: Invasion and metastasis of aggressive breast cancer cells are the final and fatal steps during cancer progression. Clinically, there are still limited therapeutic interventions for aggressive and metastatic breast cancers available. Therefore, effective, targeted, and non-toxic therapies are urgently required. Id-1, an inhibitor of basic helix-loop-helix ... Continue Reading