ABSTRACT: Research into the pharmacology of individual cannabinoids that began in the 1940s, several decades after the presence of a cannabinoid was first detected in cannabis, is concisely reviewed. Also described is how this pharmacological research led to the discovery of cannabinoid CB1 and CB2 receptors and of endogenous ligands for these receptors, to the development ... Continue Reading
STUDY: The ring test – A quantitative method for assessing the `cataleptic’ effect of cannabis in Mice
ABSTRACT: 1. A bioassay for cannabis, called the ring test, has been developed in which the percentage of the total time spent on a horizontal wire ring during which a mouse remains completely immobile is recorded. 2. The effect of cannabis on mobility is a dose-related, graded response. 3. Threshold doses of cannabis extract are 12·5 mg/kg when injected intravenously, and ... Continue Reading
STUDY: Cataleptic – The oral activity of delta’-tetrahydrocannabinol and its dependence on prostaglandin E2.
ABSTRACT: 1 delta'-trans-Tetrahydrocannabinol (THC) is more active orally in mice than previously thought, as cataleptic responses occur at doses from 0.06 mg/kg upwards, with peak activity at 2 to 4 h after dosing. These doses and peaks correspond well with the effects in man. 2 Comparison with chlorpromazine in mice shows that chlorpromazine and THC are equipotent as ... Continue Reading