ABSTRACT: Cannabis remains the most commonly abused illicit drug and is rapidly expanding in quasi-licit use in some jurisdictions under medical marijuana laws. Effects of the psychoactive constituent Δ9tetrahydrocannabinol (Δ9THC) on cognitive function remain of pressing concern. Prior studies in monkeys have not shown consistent evidence of memory specific effects of Δ9THC ... Continue Reading
Cognitive and Motor Impairments
STUDY: Δ9tetrahydrocannabinol impairs reversal learning but not extra-dimensional shifts in rhesus macaques
ABSTRACT: Expansion of medical marijuana use in the US and the recently successful decriminalization of recreational marijuana in two States elevates interest in the specific cognitive effects of Δ9tetrahydrocannabinol (Δ9THC), the major psychoactive constituent of marijuana. Controlled laboratory studies in nonhuman primates provide mixed evidence for specific effects of ... Continue Reading
STUDY: Cognitive impairment – Cannabidiol attenuates deficits of visuospatial associative memory induced by Δ9tetrahydrocannabinol
ABSTRACT: BACKGROUND AND PURPOSE Recent human studies suggest that recreational cannabis strains that are relatively high in cannabidiol (CBD) content produce less cognitive impairment than do strains with negligible CBD and similar Δ9tetrahydrocannabinol (THC) content. Self-selection in such studies means it is impossible to rule out additional variables which may ... Continue Reading
STUDY: Cannabidiol ameliorates cognitive and motor impairments in bile-duct ligated mice via 5-HT1A receptor activation
ABSTRACT: Background and purpose: We aimed to demonstrate the involvement of 5-HT1A receptors in the therapeutic effect of cannabidiol, a non-psychoactive constituent of Cannabis sativa, in a model of hepatic encephalopathy induced by bile-duct ligation (BDL) in mice. Experimental approach: Cannabidiol (5 mg·kg−1; i.p.) was administered over 4 weeks to BDL mice. ... Continue Reading