The Cannabis Advisory

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Depression

STUDY: Can Marijuana Make It Better? Prospective Effects of Marijuana and Temperament on Risk for Anxiety and Depression

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ABSTRACT: Increases in marijuana use in recent years highlight the importance of understanding how marijuana affects mental health. Of particular relevance is the effect of marijuana use on anxiety and depression given that marijuana use is highest among late adolescents/early adults, the same age range in which risk for anxiety and depression is the highest. Here we examine ... Continue Reading

STUDY: Allosteric modulation of the 5-HT3 receptor

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ABSTRACT: 5-Hydroxytryptamine type 3 (5-HT3) receptors are ligand-gated ion channels that play important roles in depression, anxiety, substance abuse, emesis, inflammatory pain, spinal nociception, gastrointestinal function, and cardiovascular reflexes. Probably the most studied modulators of 5-HT3 receptors are the high affinity competitive ‘setron’ antagonists typified by ... Continue Reading

STUDY: Allosteric modulation of the 5-HT3 receptor

Written By

ABSTRACT: 5-Hydroxytryptamine type 3 (5-HT3) receptors are ligand-gated ion channels that play important roles in depression, anxiety, substance abuse, emesis, inflammatory pain, spinal nociception, gastrointestinal function, and cardiovascular reflexes. Probably the most studied modulators of 5-HT3 receptors are the high affinity competitive ‘setron’ antagonists typified by ... Continue Reading

STUDY: Evaluation of the potential of the phytocannabinoids, cannabidivarin (CBDV) and Δ9-tetrahydrocannabivarin (THCV), to produce CB1 receptor inverse agonism symptoms of nausea in rats

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ABSTRACT: BACKGROUND AND PURPOSE The cannabinoid 1 (CB1) receptor inverse agonists/antagonists, rimonabant (SR141716, SR) and AM251, produce nausea and potentiate toxin-induced nausea by inverse agonism (rather than antagonism) of the CB1 receptor. Here, we evaluated two phytocannabinoids, cannabidivarin (CBDV) and Δ9-tetrahydrocannabivarin (THCV), for their ability to ... Continue Reading

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