ABSTRACT: 1. In anaesthetized rats, intravenous administration of cannabis extract (10 mg/kg), Δ1-tetrahydrocannabinol (THC) (0·5 mg/kg) and Δ6-THC (0·5 mg/kg) caused a reduction in systemic blood pressure, pulse rate and respiratory rate. 2. Neither cannabinol (1 mg/kg, i.v.) nor cannabidiol (1 mg/kg, i.v.) had any observed effects on the cardiovascular and respiratory ... Continue Reading
Respiratory Disorders
STUDY: Cancer – Transient receptor potential (TRP) channels: a clinical perspective
ABSTRACT: Transient receptor potential (TRP) channels are important mediators of sensory signals with marked effects on cellular functions and signalling pathways. Indeed, mutations in genes encoding TRP channels are the cause of several inherited diseases in humans (the so-called ‘TRP channelopathies’) that affect the cardiovascular, renal, skeletal and nervous systems. TRP ... Continue Reading