ABSTRACT: Cocaine is a commonly abused illicit drug that causes significant morbidity and mortality. The most severe and common complications are seizures, ischemic strokes, myocardial infarction, and acute liver injury. Here, we demonstrated that acute cocaine intoxication promoted seizure along with acute liver damage in mice, with intense inflammatory infiltrate. ... Continue Reading
Seizure
STUDY: Marijuana use and the risk of new onset seizures.
ABSTRACT: Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (542K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References. Read full study here http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2376682/ ... Continue Reading
STUDY: Cannabidivarin (CBDV) suppresses pentylenetetrazole (PTZ)-induced increases in epilepsy-related gene expression
ABSTRACT: To date, anticonvulsant effects of the plant cannabinoid, cannabidivarin (CBDV), have been reported in several animal models of seizure. However, these behaviourally observed anticonvulsant effects have not been confirmed at the molecular level. To examine changes to epilepsy-related gene expression following chemical convulsant treatment and their subsequent ... Continue Reading
STUDY: The Secret “Spice”: An Undetectable Toxic Cause of Seizure
ABSTRACT: Neurologists and emergency department physicians are frequently involved in the comprehensive evaluation of a first generalized seizure. An important aspect of this evaluation is a detailed history which can identify a provoked seizure secondary to drug toxicity and hence avoid unnecessary treatment with antiepileptic drugs. “Spice” is an umbrella term for a ... Continue Reading
STUDY: Epilepsy – Cannabidivarin is anticonvulsant in mouse and rat
ABSTRACT: Background and Purpose Phytocannabinoids in Cannabis sativa have diverse pharmacological targets extending beyond cannabinoid receptors and several exert notable anticonvulsant effects. For the first time, we investigated the anticonvulsant profile of the phytocannabinoid cannabidivarin (CBDV) in vitro and in in vivo seizure models. Experimental ... Continue Reading