ABSTRACT: We have investigated whether a 1:1 combination of botanical extracts enriched in either Δ9-tetrahydrocannabinol (Δ9-THC) or cannabidiol (CBD), which are the main constituents of the cannabis-based medicine Sativex, is neuroprotective in Huntington’s disease (HD), using an experimental model of this disease generated by unilateral lesions of the striatum with the ... Continue Reading
Δ9-tetrahydrocannabinol
STUDY: Cannabinoids and metabolites in expectorated oral fluid after 8 days of controlled around-the-clock oral THC administration
ABSTRACT: Oral fluid (OF) is an increasingly accepted matrix for drug testing programs, but questions remain about its usefulness for monitoring cannabinoids. Expectorated OF specimens (n=360) were obtained from 10 adult daily cannabis smokers before, during, and after 37 20-mg oral Δ9-tetrahydrocannabinol (THC) doses over 9 days to characterize cannabinoid disposition in ... Continue Reading
STUDY: GPR55: a new member of the cannabinoid receptor clan?
ABSTRACT: In this issue of the British Journal of Pharmacology, Ryberg et al. present convincing in vitro evidence that the orphan GPCR, GPR55, is a cannabinoid receptor. GPR55 was activated by a range of plant, synthetic and endogenous cannabinoids and blocked by the non-psychoactive phytocannabinoid, cannabidiol. Their experiments have revealed several differences between ... Continue Reading
STUDY: Cannabinoids and Metabolites in Expectorated Oral Fluid Following Controlled Smoked Cannabis
ABSTRACT: Background Δ9-Tetrahydrocannabinol (THC) in oral fluid (OF) implies cannabis intake, but eliminating passive exposure and improving interpretation of test results requires additional research. Methods Ten adult cannabis users smoked ad libitum one 6.8% THC cigarette. Expectorated OF was collected for up to 22h, and analyzed within 24 h of collection. THC, ... Continue Reading
STUDY: Cannabinoid-related agents in the treatment of anxiety disorders: current knowledge and future perspectives
ABSTRACT: Rich evidence has shown that cannabis products exert a broad gamut of effects on emotional regulation. The main psychoactive ingredient of hemp, Δ9-tetrahydrocannabinol (THC), and its synthetic cannabinoid analogs have been reported to either attenuate or exacerbate anxiety and fear-related behaviors in humans and experimental animals. The heterogeneity of ... Continue Reading