ABSTRACT: Rimonabant, the prototypic antagonist of cannabinoid CB1receptors, has been reported to have inverse agonist properties at higher concentrations, which may complicate its use as a tool for mechanistic evaluation of cannabinoid pharmacology. Consequently, recent synthesis efforts have concentrated on discovery of a neutral antagonist using a variety of structural ... Continue Reading
benefits of cannabidiol
STUDY: Δ9tetrahydrocannabinol impairs visuo-spatial associative learning and spatial working memory in rhesus macaques
ABSTRACT: Cannabis remains the most commonly abused illicit drug and is rapidly expanding in quasi-licit use in some jurisdictions under medical marijuana laws. Effects of the psychoactive constituent Δ9tetrahydrocannabinol (Δ9THC) on cognitive function remain of pressing concern. Prior studies in monkeys have not shown consistent evidence of memory specific effects of Δ9THC ... Continue Reading
STUDY: The emerging role of the endocannabinoid system in cardiovascular disease
ABSTRACT: Endocannabinoids are endogenous bioactive lipid mediators present both in the brain and various peripheral tissues, which exert their biological effects via interaction with specific G-protein-coupled cannabinoid receptors, the CB1 and CB2. Pathological overactivation of the endocannabinoid system (ECS) in various forms of shock and heart failure may contribute to ... Continue Reading
STUDY: Convulsions Associated with the Use of a Synthetic Cannabinoid Product
ABSTRACT: Introduction Clinical presentations following the use of various “spice” or synthetic cannabinoids have included agitation, anxiety, emesis, hallucinations, psychosis, tachycardia, and unresponsiveness. Convulsions were described in a one report although there was not laboratory confirmation for synthetic cannabinoids. In another published report laboratory ... Continue Reading
STUDY: Cannabidiol: Pharmacology and potential therapeutic role in epilepsy and other neuropsychiatric disorders
ABSTRACT: Objective To present a summary of current scientific evidence about the cannabinoid, cannabidiol (CBD) with regards to their relevance to epilepsy and other selected neuropsychiatric disorders. Methods We summarize the presentations from a conference in which invited participants reviewed relevant aspects of the physiology, mechanisms of action, ... Continue Reading