ABSTRACT: Δ9-tetrahydrocannabinol (THC) produces varying effects in mesenteric arteries: vasorelaxation (third-order branches, G3), modest vasorelaxation (G2), no effect (G1) and vasoconstriction (the superior mesenteric artery, G0). In G3, vasorelaxation to THC was inhibited by pertussis toxin, but was unaffected by the CB1 receptor antagonist, AM251 (1 μm), ... Continue Reading
cannabinoid receptor
A Biochemist Tells How Cannabis Oil Cured His Cancer
Refusing radiation, chemo and surgery, a biochemist treated his aggressive Stage 4 cancer with cannabis oil in just six months. He explains how cannabinoids kill cancer. This post from Reset.Me turns the spotlight on an expert’s explanation of how cannabis works on cancer cells. Vast amounts of people are coming forward to testify as to how they have treated — and in some ... Continue Reading
STUDY: So what do we call GPR18 now?
ABSTRACT: The further characterization of the orphan GPCR GPR18 conducted by McHugh et al. in this issue of the British Journal of Pharmacology has generated a pharmacological profile that raises some interesting questions about the nomenclature of this receptor and may also prompt some questions about the pharmacological definition of the classical cannabinoid receptors, CB1 ... Continue Reading
STUDY: Cannabinoid Receptors: Nomenclature and Pharmacological Principles
ABSTRACT: The CB1 and CB2 cannabinoid receptors are members of the G protein-coupled receptor (GPCR) family that are pharmacologically well defined. However, the discovery of additional sites of action for endocannabinoids as well as synthetic cannabinoid compounds suggests the existence of additional cannabinoid receptors. Here we review this evidence, as well as the ... Continue Reading
STUDY: Cannabinoid receptor 2: Potential role in immunomodulation and neuroinflammation Review
ABSTRACT: An accumulating body of evidence suggests that endocannabinoids and cannabinoid receptors type 1 and 2 (CB1, CB2) play a significant role in physiologic and pathologic processes, including cognitive and immune functions. While the addictive properties of marijuana, an extract from the Cannabis plant, are well recognized, there is growing appreciation of the ... Continue Reading