There are many remarkable things about cannabis. It has an enticing smell, lovely appearance, multiple uses, and outstanding health benefits. Interestingly, these characteristics are nearly all impacted by the compound profile of this beautiful plant. Perhaps the best-known compound manufactured in cannabis is the cannabinoid Δ9- tetrahydrocannabinol, or just ... Continue Reading
cannabinoid receptors
STUDY: Endocannabinoids and the Heart
ABSTRACT: Endocannabinoids, such as anandamide and 2-arachidonoylglycerol, are synthesized from membrane phospholipids in the heart and other cardiovascular tissues. They activate cannabinoid CB1 and CB2 receptors, TRPV1, peroxisome proliferator-activated receptors and perhaps a novel vascular G-protein-coupled receptor. Inactivation is by cellular uptake and fatty acid ... Continue Reading
STUDY: Clinical Significance of Cannabinoid Receptors CB1 and CB2 Expression in Human Malignant and Benign Thyroid Lesions
ABSTRACT: The endocannabinoid system is comprised of cannabinoid receptors (CB1 and CB2), their endogenous ligands (endocannabinoids), and proteins responsible for their metabolism participate in many different functions indispensable to homeostatic regulation in several tissues, exerting also antitumorigenic effects. The present study aimed to evaluate the clinical ... Continue Reading
STUDY: The therapeutic potential of drugs that target cannabinoid receptors or modulate the tissue levels or actions of endocannabinoids
ABSTRACT: There are at least 2 types of cannabinoid receptor, CB1 and CB2, both G protein coupled. CB1 receptors are expressed predominantly at nerve terminals and mediate inhibition of transmitter release, whereas CB2 receptors are found mainly on immune cells, their roles including the modulation of cytokine release and of immune cell migration. Endogenous agonists for ... Continue Reading
STUDY: The complications of promiscuity: endocannabinoid action and metabolism
In this review, we present our understanding of the action and metabolism of endocannabinoids and related endogenous molecules. It is clear that the interactions between the multiple endocannabinoid-like molecules (ECLs) are highly complex, both at the level of signal transduction and metabolism. Thus, ECLs are a group of ligands active at 7-transmembrane and nuclear receptors, ... Continue Reading