ABSTRACT: Purpose We have previously shown that non-psychotropic cannabidiol (CBD) protects retinal neurons in diabetic rats by inhibiting reactive oxygen species and blocking tyrosine nitration. Tyrosine nitration may inhibit glutamine synthetase (GS), causing glutamate accumulation and leading to further neuronal cell death. We propose to test the hypothesis that ... Continue Reading
Diabetes
STUDY: Retinal Microglial Activation and Inflammation Induced by Amadori-Glycated Albumin in a Rat Model of Diabetes
ABSTRACT: OBJECTIVE During diabetes, retinal microglial cells are activated to release inflammatory cytokines that initiate neuronal loss and blood–retinal barrier breakdown seen in diabetic retinopathy (DR). The mechanism by which diabetes activates microglia to release those inflammatory mediators is unclear and was therefore elucidated. RESEARCH DESIGN AND ... Continue Reading
CBD may Treat Diabetes: Research Underway, Looks Positive
This post from Diabetes.co.uk reports the findings of Israeli scientists that CBD may actually suppress, reverse and perhaps even treat diabetes, something that existing medicines are unable to do: A chemical compound from the cannabis plant, known as cannabidiol, could be used to treat diabetes, according to Israeli scientists. Treating different diseases Researchers ... Continue Reading
STUDY: An exploration of the potential mechanisms and translational potential of five medicinal plants for applications in Alzheimer’s disease
ABSTRACT: Alzheimer’s disease (AD) is the most common type of dementia, and represents a vast worldwide socio-economic burden, and in the absence of a current cure, effective therapeutic strategies are still needed. Cholinergic and cerebral blood flow deficits, excessive levels of oxidative stress, neuroinflammation and glutamate excitatory mechanisms are all believed to ... Continue Reading
STUDY: Decreased prevalence of diabetes in marijuana users: cross-sectional data from the National Health and Nutrition Examination Survey (NHANES) III
ABSTRACT: Objective To determine the association between diabetes mellitus (DM) and marijuana use. Design Cross-sectional study. Setting Data from the National Health and Nutrition Examination Survey (NHANES III, 1988–1994) conducted by the National Center for Health Statistics of the Centers for Disease Control and Prevention. Participants The study ... Continue Reading