ABSTRACT: Background and purpose: A putative novel cannabinoid receptor mediates vasorelaxation to anandamide and abnormal-cannabidiol and is blocked by O-1918 and by high concentrations of rimonabant. This study investigates VSN16, a novel water-soluble agonist, as a vasorelaxant potentially acting at non-CB1, non-CB2 cannabinoid receptors in the ... Continue Reading
endothelium
STUDY: Vasorelaxant effects of oleamide in rat small mesenteric artery indicate action at a novel cannabinoid receptor
ABSTRACT: Oleamide (cis-9-octadecenoamide) exhibits some cannabimimetic responses despite its low affinities at the currently known cannabinoid receptors. Here we have investigated whether or not it is a vasorelaxant in rat small mesenteric arteries. Oleamide elicited vasorelaxation (EC50=1.2±0.2 μm, Rmax=99.1±3.9%, n=8) which was reduced by endothelial removal. ... Continue Reading