ABSTRACT: In the present study, we found that CBD inhibited U87-MG and T98G cell proliferation and invasivenessin vitro and caused a decrease in the expression of a set of proteins specifically involved in growth, invasion and angiogenesis. In addition, CBD treatment caused a dose-related down-regulation of ERK and Akt prosurvival signaling pathways in U87-MG and T98G cells ... Continue Reading
glioma cells
STUDY: Cannabidiol inhibits human glioma cell migration through a cannabinoid receptor-independent mechanism
ABSTRACT: We evaluated the ability of cannabidiol (CBD) to impair the migration of tumor cells stimulated by conditioned medium. CBD caused concentration-dependent inhibition of the migration of U87 glioma cells, quantified in a Boyden chamber. Since these cells express both cannabinoid CB1 and CB2 receptors in the membrane, we also evaluated their engagement in the ... Continue Reading