ABSTRACT: Inhibitory (or strychnine sensitive) glycine receptors (GlyRs) are anion-selective transmitter-gated ion channels of the cys-loop superfamily, which includes among others also the inhibitory γ-aminobutyric acid receptors (GABAA receptors). While GABA mediates fast inhibitory neurotransmission throughout the CNS, the action of glycine as a fast inhibitory ... Continue Reading
glycine
STUDY: N-Acyl amino acids and N-acyl neurotransmitter conjugates: neuromodulators and probes for new drug targets
ABSTRACT: The myriad functions of lipids as signalling molecules is one of the most interesting fields in contemporary pharmacology, with a host of compounds recognized as mediators of communication within and between cells. The N-acyl conjugates of amino acids and neurotransmitters (NAANs) have recently come to prominence because of their potential roles in the nervous ... Continue Reading
STUDY: Cannabinoid potentiation of glycine receptors contributes to cannabis-induced analgesia
ABSTRACT: Cannabinoids enhance the function of glycine receptors (GlyRs). However, little is known about the mechanisms and behavioral implication of cannabinoid-GlyR interaction. Using mutagenesis and NMR analysis, we have identified a serine at 296 in the GlyR protein critical for the potentiation of IGlyby Δ9-tetrahydrocannabinol (THC), a major psychoactive component of ... Continue Reading