ABSTRACT: Marijuana's appetite-increasing effects have long been known. Recent research suggests that the CB1 cannabinoid receptor antagonist SR141716A may suppress appetite. This study represents a further, systematic investigation of the role of CB1 cannabinoid receptors in the pharmacological effects of cannabinoids on food intake. Mice were food-restricted for 24 ... Continue Reading
SR141716A
STUDY: Vasorelaxant effects of oleamide in rat small mesenteric artery indicate action at a novel cannabinoid receptor
ABSTRACT: Oleamide (cis-9-octadecenoamide) exhibits some cannabimimetic responses despite its low affinities at the currently known cannabinoid receptors. Here we have investigated whether or not it is a vasorelaxant in rat small mesenteric arteries. Oleamide elicited vasorelaxation (EC50=1.2±0.2 μm, Rmax=99.1±3.9%, n=8) which was reduced by endothelial removal. ... Continue Reading