ABSTRACT: Cannabinoid receptors and T-type calcium channels are potential targets for treating pain. Here we report on the design, synthesis and analgesic properties of a new mixed cannabinoid/T-type channel ligand, NMP-181. Results NMP-181 action on CB1 and CB2 receptors was characterized in radioligand binding and in vitro GTPĪ³[35S] functional assays, and block of ... Continue Reading
STUDY: Analgesic effect of a mixed T-type channel inhibitor/CB2 receptor agonist
