ABSTRACT: Background and purpose: N-arachidonoyl dopamine (NADA) has complex effects on nociception mediated via cannabinoid CB1 receptors and the transient receptor potential vanilloid receptor 1 (TRPV1). Anandamide, the prototypic CB1/TRPV1 agonist, also inhibits T-type voltage-gated calcium channel currents (ICa). These channels are expressed by many excitable cells, ... Continue Reading
N-arachidonoyl glycine
STUDY: Neurodegenerative Disease – N-arachidonoyl glycine, an abundant endogenous lipid, potently drives directed cellular migration through GPR18, the putative abnormal cannabidiol receptor
ABSTRACT: Background Microglia provide continuous immune surveillance of the CNS and upon activation rapidly change phenotype to express receptors that respond to chemoattractants during CNS damage or infection. These activated microglia undergo directed migration towards affected tissue. Importantly, the molecular species of chemoattractant encountered determines if ... Continue Reading