ABSTRACT: Cannabinoid receptors and T-type calcium channels are potential targets for treating pain. Here we report on the design, synthesis and analgesic properties of a new mixed cannabinoid/T-type channel ligand, NMP-181. Results NMP-181 action on CB1 and CB2 receptors was characterized in radioligand binding and in vitro GTPγ[35S] functional assays, and block of ... Continue Reading
pain
STUDY: Cannabinoids: clearing the smoke on pain, inflammation and neurodegeneration
ABSTRACT: This themed section of BJP arises from the 6th European Workshop on Cannabinoid Research held in Dublin, Ireland from 18–20 April 2013. The section brings together 3 reviews and 10 research articles, presenting a range of work across the cannabinoid field. The review article by Fagan et al. (2014) addresses the impact of endogenous, plant-derived and synthetic ... Continue Reading
New Book Puts Up the Case for Medical Marijuana’s Use and Research
This post from NPR Health discusses the new book, Stoned: A Doctor's Case for Medical Marijuana, by Dr. David Casarett, a well-respected palliative care specialist and researcher. The book delves into the medical benefits of marijuana. A year and a half ago, Dr. David Casarett did not take medical marijuana very seriously. "When I first started this project, I really thought ... Continue Reading
STUDY: The Endocannabinoid System as a Potential Therapeutic Target for Pain Modulation
ABSTRACT: Although cannabis has been used for pain management for millennia, very few approved cannabinoids are indicated for the treatment of pain and other medical symptoms. Cannabinoid therapy re-gained attention only after the discovery of endocannabinoids and fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL), the enzymes playing a role in ... Continue Reading
STUDY: The effect of cannabinoids on intestinal motility and their antinociceptive effect in mice
ABSTRACT: 1. After oral administration to mice, pethidine, Δ8-tetrahydrocannabinol (THC), Δ9-THC, a cannabis extract and cannabinol had a dose-dependent antinociceptive effect when measured by the hot-plate method. Cannabidiol was inactive at 30 mg/kg. Δ8-THC, Δ9-THC and pethidine did not differ significantly in potency, but Δ9-THC was 6·5 times more active than ... Continue Reading