ABSTRACT: Growing evidence for glutamate abnormalities in schizophrenia support the development of novel antipsychotic agents targeting this system. Early studies investigating modulation of the glutamate system using glycine, D-serine and sarcosine in patients with schizophrenia have demonstrated significant effects, particularly on negative symptoms, conventionally thought ... Continue Reading
psychosis
STUDY: Drug-Induced Psychosis: How to Avoid Star Gazing in Schizophrenia Research by Looking at More Obvious Sources of Light
ABSTRACT: The prevalent view today is that schizophrenia is a syndrome rather than a specific disease. Liability to schizophrenia is highly heritable. It appears that multiple genetic and environmental factors operate together to push individuals over a threshold into expressing the characteristic clinical picture. One environmental factor which has been curiously neglected ... Continue Reading
High Potency Cannabis Can Damage Brain Matter
A new cannabis study warns that frequent use of high potency cannabis can cause brain damage and psychosis. This post from The 420 Times reports the findings of researchers from King’s College London and Sapienza University of Rome. A new study out of the UK confirms your instincts. Potent marijuana makes you just a little bit more insane in the membrane. But ... Continue Reading
STUDY: Reversible Disruption of Pre-Pulse Inhibition in Hypomorphic-Inducible and Reversible CB1-/- Mice
ABSTRACT: Although several genes are implicated in the pathogenesis of schizophrenia, in animal models for such a severe mental illness only some aspects of the pathology can be represented (endophenotypes). Genetically modified mice are currently being used to obtain or characterize such endophenotypes. Since its cloning and characterization CB1 receptor has increasingly ... Continue Reading
STUDY: Cannabis and psychosis /schizophrenia: human studies
ABSTRACT: The association between cannabis use and psychosis has long been recognized. Recent advances in knowledge about cannabinoid receptor function have renewed interest in this association. Converging lines of evidence suggest that cannabinoids can produce a full range of transient schizophrenia-like positive, negative, and cognitive symptoms in some healthy ... Continue Reading